Detection of pepsin in sputum: a rapid and objective measure of airways reflux.

نویسندگان

  • Vicki Strugala
  • Andrew D Woodcock
  • Peter W Dettmar
  • Shoaib Faruqi
  • Alyn H Morice
چکیده

1 Verleden GM, Raghu G, Meyer KC, et al. A new classification system for chronic lung allograft dysfunction. J Heart Lung Transplant 2014; 33: 127–133. 2 Sato M, Waddell TK, Wagnetz U, et al. Restrictive allograft syndrome (RAS): a novel form of chronic lung allograft dysfunction. J Heart Lung Transplant 2011; 30: 735–742. 3 Todd JL, Jain R, Pavlisko EN, et al. Impact of forced vital capacity loss on survival after the onset of chronic lung allograft dysfunction. Am J Respir Crit Care Med 2014; 189: 159–166. 4 Verleden SE, de Jong PA, Ruttens D, et al. Functional and computed tomographic evolution and survival of restrictive allograft syndrome after lung transplantation. J Heart Lung Transplant 2014; 33: 270–277. 5 Barker AF, Bergeron A, Rom WN, et al. Obliterative bronchiolitis. N Engl J Med 2014; 370: 1820–1828. 6 Sato M, Hwang DM, Waddell TK, et al. Progression pattern of restrictive allograft syndrome after lung transplantation. J Heart Lung Transplant 2013; 32: 23–30. 7 Verleden SE, Vasilescu DM, Willems S, et al. The site and nature of airway obstruction after lung transplantation. Am J Respir Crit Care Med 2014; 189: 292–300

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Detection of pepsin in sputum: a rapid and objective measure of airways reflux

Reflux has a substantial, but as yet undefined, component in the aetiology of cough hypersensitivity syndrome [6]. Currently evaluation is by the subjective Hull Airways Reflux Questionnaire (HARQ) [7] or objective, but costly and invasive, measures such as 24-h pH-metry, impedance [8], and high resolution manometry [8, 9]. These current diagnostic pathways have their limitations in detecting l...

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Sensitive pepsin immunoassay for detection of laryngopharyngeal reflux.

OBJECTIVES/HYPOTHESIS To determine whether measurement of pepsin in throat sputum by immunoassay could be used as a sensitive and reliable method for detecting laryngopharyngeal reflux (LPR) compared with 24-hour double-probe (esophageal and pharyngeal) pH monitoring. STUDY DESIGN Patients with clinical LPR undergoing pH monitoring provided throat sputum samples during the reflux-testing peri...

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Exhaled Breath Condensate Pepsin: Potential Noninvasive Test for Gastroesophageal Reflux in COPD and Bronchiectasis.

BACKGROUND Acid gastroesophageal reflux is a common problem in non-cystic fibrosis bronchiectasis and COPD. Invasive methods are used to diagnose gastroesophageal reflux, but the ability to detect pulmonary microaspiration of gastric contents using this method is unclear. A noninvasive option to detect pulmonary microaspiration is to measure pepsin in exhaled breath condensate (EBC), but this h...

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Relevance of Measuring Substances in Bronchoalveolar Lavage Fluid for Detecting Aspiration-associated Extraesophageal Reflux Disease

c 2017 The Korean Society of Neurogastroenterology and Motility J Neurogastroenterol Motil, Vol. 23 No. 2 April, 2017 www.jnmjournal.org TO THE EDITOR: We read with great interest the paper by Özdemir et al on the assay of lipid-laden macrophages (LLMs) in broncho-alveolar lavage (BAL) fluid of patients with chronic cough as a marker of micro-aspiration of refluxate into airways. The authors fo...

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Pulmonary Scintiscan Findings in Sulfur Mustard Injured Patients Suspected for Gastroesophageal Reflux; a Descriptive Cross-Sectional Study

Background:Gastroesophageal reflux disease (GERD) prevalence in patients with sulfur mustard (SM)-induced bronchiolitis obliterans (BO) is higher than exposed cases with mild lung injuries. In this study, we aimed to evaluate the prevalence of microaspirations using nuclear scintiscan among BO patients with SM exposure. Methods: This was a prospective cross-sectional study conducted on patient...

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عنوان ژورنال:
  • The European respiratory journal

دوره 47 1  شماره 

صفحات  -

تاریخ انتشار 2016